Undergraduate biomedical engineering capstone completed in 2016–2017.
Capstone engineering
Low-Cost Nanoparticle Analyzer Capstone
Biomedical engineering capstone combining fluorescence microscopy, microfluidics, and Brownian-motion tracking in a ~$4,500 prototype with <$5 chambers and <1.9% sizing error across 50 nm to 1 µm particles.
completed2016–2017CapstoneOptical sensingMicrofluidicsBiomedical engineering
Typeundergraduate capstone
SkillsFluorescence microscopy, Microfluidics, Brownian-motion tracking, System validation
Selected facts
Quantitative details and source-backed proof points.
Prototype cost: approximately $4,500, with disposable chamber cost below $5 each.
Sizing error: below 1.9% across particles from 50 nm to 1 µm.
Method: fluorescence microscopy with Brownian-motion tracking in microfluidic chambers.
Project summary
Why it exists, what I built, and what I learned.
Why I built it
The capstone explored a lower-cost approach to nanoparticle sizing by combining inexpensive microfluidic chambers with optical tracking and analysis.
What I built
A fluorescence-microscopy and microfluidic measurement system with disposable chambers, image acquisition, Brownian-motion tracking, calibration, and prototype validation.
What worked
Integrating the optical setup, chamber design, tracking workflow, and calibration produced sizing error below 1.9% across 50 nm to 1 µm particles.
What failed
Measurement quality was sensitive to illumination, chamber consistency, particle tracking, and analysis assumptions, requiring iteration across optics, microfluidics, and software.
What I learned
The measurement only became reliable when optics, chamber fabrication, calibration, and particle-tracking analysis were engineered as one system.
Stack
Tools, systems, and technical areas involved.
Fluorescence microscopyMicrofluidic chambersBrownian-motion trackingImage analysisCalibrationPDR / CDR
Links and direction
Public links and next steps.
Use this page as standalone undergraduate capstone evidence rather than attributing it to an employment role.
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